Impaired heteronymous somatosensory motor cortical inhibition in dystonia
Identifieur interne : 004065 ( Main/Exploration ); précédent : 004064; suivant : 004066Impaired heteronymous somatosensory motor cortical inhibition in dystonia
Auteurs : Laura Bertolasi [Italie] ; Silvia Romito [Italie] ; Michele Tinazzi [Italie] ; Niccol Rizzuto [Italie] ; Alberto Priori [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 2003-11.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Adult, Dystonia, Dystonia Musculorum Deformans (diagnosis), Dystonia Musculorum Deformans (physiopathology), Electric Stimulation (instrumentation), Evoked Potentials, Motor (physiology), Evoked Potentials, Somatosensory (physiology), Evoked potential, Female, Functional Laterality (physiology), Human, Humans, Inhibition, Magnetic, Male, Median Nerve (physiology), Middle Aged, Motor Cortex (physiopathology), Motor cortex, Motor evoked potential, Muscle, Skeletal (innervation), Muscle, Skeletal (physiopathology), Neural Inhibition (physiology), Pathophysiology, Skull, Stimulation, Transcranial route, antagonist cortical inhibition, dystonia, motor cortex, muscle afferents, transcranial brain stimulation.
- MESH :
- diagnosis : Dystonia Musculorum Deformans.
- innervation : Muscle, Skeletal.
- instrumentation : Electric Stimulation.
- physiology : Evoked Potentials, Motor, Evoked Potentials, Somatosensory, Functional Laterality, Median Nerve, Neural Inhibition.
- physiopathology : Dystonia Musculorum Deformans, Motor Cortex, Muscle, Skeletal.
- Adult, Female, Humans, Male, Middle Aged, Skull.
Abstract
A typical pathophysiological abnormality in dystonia is cocontraction of antagonist muscles, with impaired reciprocal inhibitory mechanisms in the spinal cord. Recent experimental data have shown that inhibitory interactions between antagonist muscles have also a parallel control at the level of the sensorimotor cortex. The aim of this work was to study heteronymous effects of a median nerve stimulus on the corticospinal projections to forearm muscles in dystonia. We used the technique of antagonist cortical inhibition, which assesses the conditioning effect of median nerve afferent input on motor evoked potentials (MEPs) elicited by transcranial magnetic stimulation (TMS) in ipsilateral forearm extensor muscles at rest. Nine healthy subjects and 10 patients with torsion dystonia participated in the study. MEPs and somatosensory evoked potentials were normal in patients. In healthy subjects, median nerve stimulation at 15‐ to 18‐msec intervals inhibited the test MEPs in forearm extensors. In dystonic patients, median nerve stimulation delivered at the same conditioning–test intervals elicited significantly less inhibition of the test MEP. On the whole, these data suggest an impaired sensory–motor integration in dystonia and, more specifically, the decreased antagonistic cortical inhibition could suggest that functional interactions between antagonist muscles are primarily impaired at the cortical level. © 2003 Movement Disorder Society
Url:
DOI: 10.1002/mds.10514
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000905
- to stream Istex, to step Curation: 000905
- to stream Istex, to step Checkpoint: 002995
- to stream PubMed, to step Corpus: 003626
- to stream PubMed, to step Curation: 003626
- to stream PubMed, to step Checkpoint: 003757
- to stream Ncbi, to step Merge: 000C38
- to stream Ncbi, to step Curation: 000C38
- to stream Ncbi, to step Checkpoint: 000C38
- to stream Main, to step Merge: 005C88
- to stream PascalFrancis, to step Corpus: 002311
- to stream PascalFrancis, to step Curation: 000A10
- to stream PascalFrancis, to step Checkpoint: 002431
- to stream Main, to step Merge: 005F77
- to stream Main, to step Curation: 004065
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Impaired heteronymous somatosensory motor cortical inhibition in dystonia</title><author><name sortKey="Bertolasi, Laura" sort="Bertolasi, Laura" uniqKey="Bertolasi L" first="Laura" last="Bertolasi">Laura Bertolasi</name></author><author><name sortKey="Romito, Silvia" sort="Romito, Silvia" uniqKey="Romito S" first="Silvia" last="Romito">Silvia Romito</name></author><author><name sortKey="Tinazzi, Michele" sort="Tinazzi, Michele" uniqKey="Tinazzi M" first="Michele" last="Tinazzi">Michele Tinazzi</name></author><author><name sortKey="Rizzuto, Niccol" sort="Rizzuto, Niccol" uniqKey="Rizzuto N" first="Niccol" last="Rizzuto">Niccol Rizzuto</name></author><author><name sortKey="Priori, Alberto" sort="Priori, Alberto" uniqKey="Priori A" first="Alberto" last="Priori">Alberto Priori</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:B1C4F11AB2EE568A0E66A3AE07592BCAFBCBA29F</idno><date when="2003" year="2003">2003</date><idno type="doi">10.1002/mds.10514</idno><idno type="url">https://api.istex.fr/document/B1C4F11AB2EE568A0E66A3AE07592BCAFBCBA29F/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000905</idno><idno type="wicri:Area/Istex/Curation">000905</idno><idno type="wicri:Area/Istex/Checkpoint">002995</idno><idno type="wicri:doubleKey">0885-3185:2003:Bertolasi L:impaired:heteronymous:somatosensory</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:14639683</idno><idno type="wicri:Area/PubMed/Corpus">003626</idno><idno type="wicri:Area/PubMed/Curation">003626</idno><idno type="wicri:Area/PubMed/Checkpoint">003757</idno><idno type="wicri:Area/Ncbi/Merge">000C38</idno><idno type="wicri:Area/Ncbi/Curation">000C38</idno><idno type="wicri:Area/Ncbi/Checkpoint">000C38</idno><idno type="wicri:doubleKey">0885-3185:2003:Bertolasi L:impaired:heteronymous:somatosensory</idno><idno type="wicri:Area/Main/Merge">005C88</idno><idno type="wicri:source">INIST</idno><idno type="RBID">Pascal:04-0130001</idno><idno type="wicri:Area/PascalFrancis/Corpus">002311</idno><idno type="wicri:Area/PascalFrancis/Curation">000A10</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">002431</idno><idno type="wicri:doubleKey">0885-3185:2003:Bertolasi L:impaired:heteronymous:somatosensory</idno><idno type="wicri:Area/Main/Merge">005F77</idno><idno type="wicri:Area/Main/Curation">004065</idno><idno type="wicri:Area/Main/Exploration">004065</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Impaired heteronymous somatosensory motor cortical inhibition in dystonia</title><author><name sortKey="Bertolasi, Laura" sort="Bertolasi, Laura" uniqKey="Bertolasi L" first="Laura" last="Bertolasi">Laura Bertolasi</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences and Vision, Section of Neurology, University of Verona, Verona</wicri:regionArea><wicri:noRegion>Verona</wicri:noRegion></affiliation></author><author><name sortKey="Romito, Silvia" sort="Romito, Silvia" uniqKey="Romito S" first="Silvia" last="Romito">Silvia Romito</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences and Vision, Section of Neurology, University of Verona, Verona</wicri:regionArea><wicri:noRegion>Verona</wicri:noRegion></affiliation></author><author><name sortKey="Tinazzi, Michele" sort="Tinazzi, Michele" uniqKey="Tinazzi M" first="Michele" last="Tinazzi">Michele Tinazzi</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences and Vision, Section of Neurology, University of Verona, Verona</wicri:regionArea><wicri:noRegion>Verona</wicri:noRegion></affiliation></author><author><name sortKey="Rizzuto, Niccol" sort="Rizzuto, Niccol" uniqKey="Rizzuto N" first="Niccol" last="Rizzuto">Niccol Rizzuto</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences and Vision, Section of Neurology, University of Verona, Verona</wicri:regionArea><wicri:noRegion>Verona</wicri:noRegion></affiliation></author><author><name sortKey="Priori, Alberto" sort="Priori, Alberto" uniqKey="Priori A" first="Alberto" last="Priori">Alberto Priori</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Neurology, University of Milano, IRCCS, Ospedale Maggiore Policlinico, Milano</wicri:regionArea><wicri:noRegion>Milano</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2003-11">2003-11</date><biblScope unit="vol">18</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1367">1367</biblScope><biblScope unit="page" to="1373">1373</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">B1C4F11AB2EE568A0E66A3AE07592BCAFBCBA29F</idno><idno type="DOI">10.1002/mds.10514</idno><idno type="ArticleID">MDS10514</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Dystonia</term><term>Dystonia Musculorum Deformans (diagnosis)</term><term>Dystonia Musculorum Deformans (physiopathology)</term><term>Electric Stimulation (instrumentation)</term><term>Evoked Potentials, Motor (physiology)</term><term>Evoked Potentials, Somatosensory (physiology)</term><term>Evoked potential</term><term>Female</term><term>Functional Laterality (physiology)</term><term>Human</term><term>Humans</term><term>Inhibition</term><term>Magnetic</term><term>Male</term><term>Median Nerve (physiology)</term><term>Middle Aged</term><term>Motor Cortex (physiopathology)</term><term>Motor cortex</term><term>Motor evoked potential</term><term>Muscle, Skeletal (innervation)</term><term>Muscle, Skeletal (physiopathology)</term><term>Neural Inhibition (physiology)</term><term>Pathophysiology</term><term>Skull</term><term>Stimulation</term><term>Transcranial route</term><term>antagonist cortical inhibition</term><term>dystonia</term><term>motor cortex</term><term>muscle afferents</term><term>transcranial brain stimulation</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Dystonia Musculorum Deformans</term></keywords><keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Muscle, Skeletal</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Electric Stimulation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Evoked Potentials, Motor</term><term>Evoked Potentials, Somatosensory</term><term>Functional Laterality</term><term>Median Nerve</term><term>Neural Inhibition</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Dystonia Musculorum Deformans</term><term>Motor Cortex</term><term>Muscle, Skeletal</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Skull</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Cortex moteur</term><term>Dystonie</term><term>Homme</term><term>Inhibition</term><term>Magnétique</term><term>Physiopathologie</term><term>Potentiel évoqué</term><term>Potentiel évoqué moteur</term><term>Stimulation</term><term>Voie transcrânienne</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A typical pathophysiological abnormality in dystonia is cocontraction of antagonist muscles, with impaired reciprocal inhibitory mechanisms in the spinal cord. Recent experimental data have shown that inhibitory interactions between antagonist muscles have also a parallel control at the level of the sensorimotor cortex. The aim of this work was to study heteronymous effects of a median nerve stimulus on the corticospinal projections to forearm muscles in dystonia. We used the technique of antagonist cortical inhibition, which assesses the conditioning effect of median nerve afferent input on motor evoked potentials (MEPs) elicited by transcranial magnetic stimulation (TMS) in ipsilateral forearm extensor muscles at rest. Nine healthy subjects and 10 patients with torsion dystonia participated in the study. MEPs and somatosensory evoked potentials were normal in patients. In healthy subjects, median nerve stimulation at 15‐ to 18‐msec intervals inhibited the test MEPs in forearm extensors. In dystonic patients, median nerve stimulation delivered at the same conditioning–test intervals elicited significantly less inhibition of the test MEP. On the whole, these data suggest an impaired sensory–motor integration in dystonia and, more specifically, the decreased antagonistic cortical inhibition could suggest that functional interactions between antagonist muscles are primarily impaired at the cortical level. © 2003 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Bertolasi, Laura" sort="Bertolasi, Laura" uniqKey="Bertolasi L" first="Laura" last="Bertolasi">Laura Bertolasi</name></noRegion><name sortKey="Priori, Alberto" sort="Priori, Alberto" uniqKey="Priori A" first="Alberto" last="Priori">Alberto Priori</name><name sortKey="Rizzuto, Niccol" sort="Rizzuto, Niccol" uniqKey="Rizzuto N" first="Niccol" last="Rizzuto">Niccol Rizzuto</name><name sortKey="Romito, Silvia" sort="Romito, Silvia" uniqKey="Romito S" first="Silvia" last="Romito">Silvia Romito</name><name sortKey="Tinazzi, Michele" sort="Tinazzi, Michele" uniqKey="Tinazzi M" first="Michele" last="Tinazzi">Michele Tinazzi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004065 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004065 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:B1C4F11AB2EE568A0E66A3AE07592BCAFBCBA29F
|texte= Impaired heteronymous somatosensory motor cortical inhibition in dystonia
}}
| This area was generated with Dilib version V0.6.23. |  |